TY - JOUR AU - Zlamal, Jan AU - Bakchoul, Tamam PY - 2018 TI - Acquired immune thrombocytopenia: an update on pathophysiology, diagnosis and management JF - Annals of Blood; Vol 3 (November 2018): Annals of Blood Y2 - 2018 KW - N2 - Acquired thrombocytopenias represent a group of bleeding diseases which can be mediated by immune or non-immune factors. Acquired immune thrombocytopenia (AITP) leads to an accelerated decrease in platelet count by platelet reactive antibodies arising from several mechanisms. In AITP, autoantibodies (AAbs), alloantibodies or drug-dependent antibodies (DDAbs) are usually targeting platelet surface glycoproteins (GPs). The consequence of this is a significant decrease in the number of circulating platelets, leading to clinicopathological disorders including immune thrombocytopenia (ITP), heparin-induced thrombocytopenia (HIT) or drug-induced thrombocytopenia (DITP), respectively. The aforementioned disorders are characterized by a severe reduction in platelet count ( 9 /L) which is, with the exception of HIT, associated with high bleeding risk. In this review we provide current insight into recent achievements regarding pathophysiology, diagnosis and management of AITP. UR - https://aob.amegroups.org/article/view/4700